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In vivo analysis of influenza A mRNA secondary structures identifies critical regulatory motifs

23 Apr 2019

Abstract excerpt

The influenza A virus (IAV) is a continuous health threat to humans as well as animals due to its recurring epidemics and pandemics. The IAV genome is segmented and the eight negative-sense viral RNAs (vRNAs) are transcribed into positive sense complementary RNAs (cRNAs) and viral messenger RNAs (mRNAs) inside infected host cells. A role for the secondary structure of IAV mRNAs has been hypothesized and debated...

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PMID: 31053845
DOI: 10.1093/nar/gkz318

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