Article

Adaptive Kinase Signalling Enables Escape from Small Molecule Inhibition in Glioblastoma

2025-10-28

Abstract excerpt

Patients with glioblastoma (GB) have a median survival of 15 months. Despite an intensive treatment schedule with resection, radio- and chemotherapy, recurrence is inevitable. A significant challenge to overcome GB treatment resistance involves intratumoral heterogeneity, characterized by molecular, phenotypic, and clinical distinctive GB subtypes. Different small molecule inhibitors (SMI) have been designed to in...

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Literature Corpus work: bee8031b-0b5a-55f7-8008-82ebb8c1de28
DOI: 10.1101/2025.10.28.684838

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