Article

Monotherapy efficacy of BBB-permeable small molecule activators of PP2A in glioblastoma

2019-09-23

Abstract excerpt

Glioblastoma (GB) is a fatal disease in which most targeted therapies have clinically failed. However, pharmacological reactivation of tumor suppressors has not been thoroughly studied as yet as a GB therapeutic strategy. Tumor suppressor Protein Phosphatase 2A (PP2A), is inhibited by non-genetic mechanisms in GB, and thus it would be potentially amendable for therapeutic reactivation. Here we demonstrate, that s...

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Literature Corpus work: c8817e6a-1d24-5b0b-82f6-9bd1f5168899
DOI: 10.1101/777276

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