Article
High-throughput screening uncovers miRNAs enhancing glioblastoma cell susceptibility to tyrosine kinase inhibitors.
Human molecular genetics - 15 Nov 2017
Cunha Pedro P, Costa Pedro M, Morais Catarina M, Lopes Inês R, Cardoso Ana M, Cardoso Ana L, Mano Miguel, Jurado Amália S, Pedroso de Lima Maria C
Abstract excerpt
Glioblastoma (GBM) is a deadly and therapy resistant malignant brain tumour, characterized by an aggressive and diffuse growth pattern, which prevents complete surgical resection. Despite advances in the identification of genomic and molecular alterations that fuel the tumour, average patient survival post-diagnosis remains very low (∼14.6-months). In addition to being highly heterogeneous, GBM tumour cells...
Topics
Join the communities discussing this publication.