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Article

How to train glioma cells to die: molecular challenges in cell death

5 Nov 2015

Abstract excerpt

The five-year survival rate for patients with malignant glioma is less than 10%. Despite aggressive chemo/radiotherapy these tumors have remained resistant to almost every interventional strategy evaluated in patients. Resistance to these agents is attributed to extrinsic mechanisms such as the tumor microenvironment, poor drug penetration, and tumoral heterogeneity. In addition, genetic and molecular examination...

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PMID: 26542029
DOI: 10.1007/s11060-015-1980-1

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