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Article

Patient-derived tumor organoids mimic treatment-induced DNA damage response in glioblastoma

31 Jul 2024

Abstract excerpt

Glioblastoma (GB) is the most common primary malignant brain tumor, characterized by resistance to therapy. Despite aggressive treatment options, GB remains an incurable disease. Invasiveness and heterogeneity are key GB features that cannot be studied in preclinical in vitro models. In this study, we investigated the effects of standard therapy using patient-derived GB organoids (GBOs). GBOs reflect the...

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PMID: 39252971
DOI: 10.1016/j.isci.2024.110604

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