Article
Identification, Selection and Immune Assessment of Liver Stage CD8 T Cell Epitopes From Plasmodium falciparum.
Frontiers in immunology - 1 Jan 2021
Tucker Kenneth D, Schanen Brian C, Phares Timothy W, Sassano Emily, Terry Frances E, Hindocha Pooja, Moise Leonard, Kotraiah Vinayaka, Martin William D, De Groot Anne S, Drake Donald R, Gutierrez Gabriel M, Noe Amy R
Abstract excerpt
Immunization with radiation-attenuated sporozoites (RAS) has been shown to protect against malaria infection, primarily through CD8 T cell responses, but protection is limited based on parasite strain. Therefore, while CD8 T cells are an ideal effector population target for liver stage malaria vaccine development strategies, such strategies must incorporate conserved epitopes that cover a large range of class I...
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