Article

Pathogenic NLRP3 mutants forms constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production

2024-11-13

Abstract excerpt

<title>Abstract</title> <p>Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory condition resulting from monoallelic <italic>NLRP3</italic> variants that facilitate IL-1β production. Although these are gain-of-function variants characterised by hypersensitivity to cell priming, patients with CAPS and animal models of the disease may present inflammatory flares without identifiable external trigger...

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Literature Corpus work: 62440e72-0ea2-5430-bff0-500f7ba21178
DOI: 10.21203/rs.3.rs-2884955/v1

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