Article

NLRP1 inflammasome activation in skin equivalents reveals mechanistic insights into the roles of keratinocytes in psoriasis

2025-06-27

Abstract excerpt

<h4>ABSTRACT</h4> Psoriasis is a major inflammatory skin disease for which a causal therapy is still not available. The pro-inflammatory cytokines interleukin(IL)-1β and IL-36γ are key drivers of the disease phenotype, but the mechanisms underlying their regulation in psoriasis remain poorly understood. Generation of IL-1β activity is regulated by protein complexes, termed inflammasomes. We activated the NLRP1 in...

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Literature Corpus work: 4674e313-8dfb-5031-94b7-c9666544bb33
DOI: 10.1101/2025.06.25.661501

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