Article

Leveraging GWAS Data Derived From a Large Cooperative Group Trial to Identify a SNP Cluster Associated With the Risk of Taxane-induced Peripheral Neuropathy

2021-02-23

Abstract excerpt

<h4>Background: </h4> Chemotherapy-induced peripheral neuropathy (CIPN) is a common toxicity of taxanes for which there is no effective intervention. Genomic CIPN risk determination has yielded promising, but inconsistent results. The present study assessed the utility of a collective SNP cluster identified using novel analytic to describe taxane-associated CIPN risk.MethodsWe analyzed GWAS data derived from ECOG-...

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Literature Corpus work: bec8d660-9487-5f37-932c-413aa1bd8c0d
DOI: 10.21203/rs.3.rs-219649/v1

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