Genome-Wide Association Studies for Taxane-Induced Peripheral Neuropathy in ECOG-5103 and ECOG-1199.

doi:10.1158/1078-0432.CCR-15-0586

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Genome-Wide Association Studies for Taxane-Induced Peripheral Neuropathy in ECOG-5103 and ECOG-1199.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2015

Schneider Bryan P, Li Lang, Radovich Milan, Shen Fei, Miller Kathy D, Flockhart David A, Jiang Guanglong, Vance Gail, Gardner Laura, Vatta Matteo, Bai Shaochun, Lai Dongbing, Koller Daniel, Zhao Fengmin, O'Neill Anne, Smith Mary Lou, Railey Elda, White Carol, Partridge Ann, Sparano Joseph, Davidson Nancy E, Foroud Tatiana, Sledge George W

Abstract excerpt

PURPOSE: Taxane-induced peripheral neuropathy (TIPN) is an important survivorship issue for many cancer patients. Currently, there are no clinically implemented biomarkers to predict which patients might be at increased risk for TIPN. We present a comprehensive approach to identification of genetic variants to predict TIPN. EXPERIMENTAL DESIGN: We performed a genome-wide association study (GWAS) in 3,431 patients...

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PMID: 26138065
DOI: 10.1158/1078-0432.CCR-15-0586
PMCID: PMC4717479

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