Article
Leveraging GWAS data derived from a large cooperative group trial to assess the risk of taxane-induced peripheral neuropathy (TIPN) in patients being treated for breast cancer: Part 2-functional implications of a SNP cluster associated with TIPN risk in patients being treated for breast cancer.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer - 21 Feb 2023
Lustberg Maryam, Wu Xuan, Fernández-Martínez Juan Luis, de Andrés-Galiana Enrique J, Philips Santosh, Leibowitz Jeffrey, Schneider Bryan, Sonis Stephen
Abstract excerpt
INTRODUCTION: Using GWAS data derived from a large collaborative trial (ECOG-5103), we identified a cluster of 267 SNPs which predicted CIPN in treatment-naive patients as reported in Part 1 of this study. To assess the functional and pathological implications of this set, we identified collective gene signatures were and evaluated the informational value of those signatures in defining CIPN's pathogenesis....
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