Article

Gα <sub>q/11</sub> signalling counteracts endothelial dysfunction in the brain and protects cognition in aged mice

2025-07-29

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Cerebral small vessel disease (cSVD) is a major cause of stroke and dementia, and is associated with increased blood-brain barrier permeability, neuroinflammation, and endothelial dysfunction. Endothelial Gα q/11 proteins are involved in vascular tone regulation and have been shown to affect capillary blood flow in the brain. Since factors downstream of activated Gα q/11 p...

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Literature Corpus work: 2e3b6102-be3f-5e9d-8596-0f86dcfe9c6d
DOI: 10.1101/2025.07.24.666499

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