Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans.

doi:10.1161/JAHA.115.002757

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Article

Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans.

Journal of the American Heart Association - 22 Feb 2016

Hattori Yorito, Enmi Jun-Ichiro, Iguchi Satoshi, Saito Satoshi, Yamamoto Yumi, Tsuji Masahiro, Nagatsuka Kazuyuki, Kalaria Rajesh N, Iida Hidehiro, Ihara Masafumi

Abstract excerpt

BACKGROUND: Existing rodent models of vascular cognitive impairment (VCI) show abrupt changes in cerebral blood flow (CBF) and do not reliably replicate the clinical pathogenesis of VCI. We therefore aimed to develop a mouse model of VCI where CBF is gradually reduced, followed by subsequent progressive motor and cognitive impairment, after surgical intervention. METHODS AND RESULTS: Adult C57BL/6J male mice were...

Topics

Animals
Behavior, Animal
Brain
Carotid Arteries
Carotid Stenosis
Cerebral Angiography
Cerebrovascular Circulation
Cognition
Cognition Disorders
Collateral Circulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Dementia, Vascular

Disease Models, Animal

Disease Progression

Humans

Magnetic Resonance Angiography

Male

Maze Learning

Mice, Inbred C57BL

Source

Open in PubMed Open full text

Identifiers

PMID: 26903005
DOI: 10.1161/JAHA.115.002757
PMCID: PMC4802480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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