Article

mAbClust with AlphaFold 3 avoids hallucinations to define a quaternary broadly neutralizing HCV epitope

2026-01-07

Abstract excerpt

<h4>Summary</h4> The hepatitis C virus (HCV) envelope glycoprotein E1E2 heterodimer is the target of broadly neutralizing antibodies (bNAbs). Although prior studies have indicated that E1-dependent bNAbs are associated with spontaneous clearance of HCV, all E1-dependent human monoclonal antibodies (mAbs) have been isolated from individuals with chronic HCV infection. Here, we isolated E1-dependent bNAbs from an i...

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Literature Corpus work: bea970f8-9a77-574a-8d14-fa721cfa2813
DOI: 10.64898/2026.01.06.698032

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