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Article

Structural basis for broad neutralization of hepatitis C virus quasispecies.

PloS one - 1 Jan 2011

Lapierre Pascal, Troesch Myriam, Alvarez Fernando, Soudeyns Hugo

Abstract excerpt

Monoclonal antibodies directed against hepatitis C virus (HCV) E2 protein can neutralize cell-cultured HCV and pseudoparticles expressing envelopes derived from multiple HCV subtypes. For example, based on antibody blocking experiments and alanine scanning mutagenesis, it was proposed that the AR3B monoclonal antibody recognized a discontinuous conformational epitope comprised of amino acid residues 396-424,...

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Share to Antibodies, Monoclonal
Share to Antibodies, Neutralizing
Share to Encephalitis Viruses, Tick-Borne

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22046426
DOI: 10.1371/journal.pone.0026981
PMCID: PMC3202596

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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