Article

Structure and misfolding of the flexible tripartite coiled coil domain of glaucoma-associated myocilin

2017-06-23

Abstract excerpt

<h4>Summary</h4> Glaucoma-associated myocilin is a member of the olfactomedins, a protein family broadly involved in neuronal development and human disease. Molecular studies of the myocilin N-terminal coiled coil demonstrate a unique tripartite architecture: a disulfide-linked, parallel dimer-of-dimers Y-shaped molecule, with distinct tetramer and dimer regions. The structure of the C-terminal 7-heptad dimer elu...

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Literature Corpus work: 9e2fe588-a0ee-52c7-a6c4-277298e8d0c6
DOI: 10.1101/154112

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