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Article

Integrated multiomics of pressure overload in the human heart prioritizes targets relevant to heart failure

26 Jul 2025

Abstract excerpt

Pressure overload initiates a series of alterations in the human heart that predate macroscopic organ-level remodeling and downstream heart failure. We study aortic stenosis through integrated proteomic, tissue transcriptomic, and genetic methods to prioritize targets causal in human heart failure. First, we identify the circulating proteome of cardiac remodeling in aortic stenosis, specifying known and...

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Share to Cardiac Fibrosis and Remodeling
Share to Cardiac Valve Diseases and Treatments
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40715126
DOI: 10.1038/s41467-025-62201-2

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