Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Age-dependent transcriptional alterations in cardiac endothelial cells

7 Jun 2021

Abstract excerpt

Aging is a significant risk factor for cardiovascular disease. Despite the fact that endothelial cells play critical roles in cardiovascular function and disease, the molecular impact of aging on this cell population in many organ systems remains unknown. In this study, we sought to determine age-associated transcriptional alterations in cardiac endothelial cells. Highly enriched populations of endothelial cells...

Topics

Join the communities discussing this publication.

Apelin-related biomedical research
Lipid metabolism and disorders
Nuclear Receptors and Signaling

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34097533
DOI: 10.1152/physiolgenomics.00037.2021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Age-dependent transcriptional alterations in cardiac endothelial cellsPMID 34097533Read ↗

EndoAge Atlas: Non-linear dynamics of endothelial aging reveal organ-specific vascular trajectories in miceSemantic proximity Read ↗

Single-Cell Transcriptional Profiling Reveals Sex and Age Diversity of Gene Expression in Mouse Endothelial CellsSemantic proximity Read ↗

Uncovering the transcriptional hallmarks of endothelial cell aging via integrated single-cell analysisSemantic proximity Read ↗

Identification of cellular heterogeneity and key signaling pathways associated with vascular remodeling and calcification in young and old primate aortas based on single-cell analysisSemantic proximity Read ↗

Age-associated changes in endothelial transcriptome and chromatin landscape correlate with elevated risk of hemorrhageSemantic proximity Read ↗

Aging-associated changes in cardiac gene expressionSemantic proximity Read ↗

Age-associated erosion of organ-specific endothelial programs compromises tissue function and resilienceSemantic proximity Read ↗

Zonation-dependent single-endothelial cell transcriptomic changes in the aged brainSemantic proximity Read ↗

Cardiovascular disease risk factors induce mesenchymal features and senescence in cardiac endothelial cellsSemantic proximity Read ↗

Single-Cell RNA Sequencing and Assay for Transposase-Accessible Chromatin Using Sequencing Reveals Cellular and Molecular Dynamics of Aortic Aging in MiceSemantic proximity Read ↗

Unravelling the impact of aging on the human endothelial lncRNA transcriptomeSemantic proximity Read ↗

Age‐Associated Changes in Endothelial Transcriptome and Epigenetic Landscapes Correlate With Elevated Risk of Cerebral MicrobleedsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.