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Article

Single-Cell RNA sequencing investigation of female-male differences under PAD conditions

7 Sept 2023

Abstract excerpt

Peripheral arterial disease (PAD) is an age-related medical condition affecting mostly muscular arteries of the limb. It is the 3rd leading cause of atherosclerotic morbidity. The mechanical environment of endothelial cells (ECs) in PAD is characterized by disturbed blood flow (d-flow) and stiff extracellular matrices. In PAD, the stiffness of arteries is due to decreased elastin function and increased collagen...

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PMID: 37745110
DOI: 10.3389/fcvm.2023.1251141

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