Article
Membrane association of monotopic phosphoglycosyl transferase underpins function.
Nature chemical biology - 1 Jun 2018
Ray Leah C, Das Debasis, Entova Sonya, Lukose Vinita, Lynch Andrew J, Imperiali Barbara, Allen Karen N
Abstract excerpt
Polyprenol phosphate phosphoglycosyl transferases (PGTs) catalyze the first membrane-committed step in assembly of essential glycoconjugates. Currently there is no structure-function information to describe how monotopic PGTs coordinate the reaction between membrane-embedded and soluble substrates. We describe the structure and mode of membrane association of PglC, a PGT from Campylobacter concisus. The structure...
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