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Article

A small molecule high throughput screening platform to profile conformational properties of nascent, ribosome-bound proteins.

Scientific reports - 15 Feb 2022

Shishido Hideki, Yoon Jae Seok, Skach William R

Abstract excerpt

Genetic mutations cause a wide spectrum of human disease by disrupting protein folding, both during and after synthesis. Transient de-novo folding intermediates therefore represent potential drug targets for pharmacological correction of protein folding disorders. Here we develop a FRET-based high-throughput screening (HTS) assay in 1,536-well format capable of identifying small molecules that interact with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35169219
DOI: 10.1038/s41598-022-06456-5
PMCID: PMC8847357

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