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Genome-scale dissection of phase-variable gene function in <i>Campylobacter jejuni</i> using a stabilized phasotype library

2025-12-15

Abstract excerpt

Phase variation (PV) enables bacterial pathogens to rapidly alter their surface structures through reversible mutations in simple sequence repeats, promoting immune evasion and environmental adaptation. In Campylobacter jejuni , the stochastic nature of PV has hindered the systematic functional analysis of phase-variable genes (PVGs). Here, we introduce PV-GenShift, a genome-scale screening platform built on a ge...

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Literature Corpus work
35ec0233-b416-50c7-92b8-35cdb73f5997
DOI
10.64898/2025.12.14.694251
Open publication

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Genome-scale dissection of phase-variable gene function in <i>Campylobacter jejuni</i> using a stabilized phasotype libraryDOI 10.64898/2025.12.14.694251
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