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Genetic Risk of Reticular Pseudodrusen in Age-Related Macular Degeneration: <i>HTRA1</i> /lncRNA <i>BX842242.1</i> dominates, with no evidence for Complement Cascade involvement

2024-09-28

Abstract excerpt

Age-related macular degeneration (AMD) is a multifactorial retinal disease with a large genetic risk contribution. Reticular pseudodrusen (RPD) is a sub-phenotype of AMD with a high risk of progression to late vision threatening AMD. In a genome-wide association study of 2,165 AMD+/RPD+ and 4,181 AMD+/RPD-compared to 7,660 control participants, both chromosomes 1 ( CFH ) and 10 ( ARMS2/HTRA1 ) major AMD risk loc...

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Literature Corpus work
ebdf8590-3df4-53e8-ab25-e15a36a9177a
DOI
10.1101/2024.09.26.24314339
Open publication

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Genetic Risk of Reticular Pseudodrusen in Age-Related Macular Degeneration: <i>HTRA1</i> /lncRNA <i>BX842242.1</i> dominates, with no evidence for Complement Cascade involvementDOI 10.1101/2024.09.26.24314339
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