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Article

A Pilot Application of an iTRAQ-Based Proteomics Screen Estimates the Effects of Cigarette Smokers' Serum on RPE Cells With AMD High-Risk Alleles.

Translational vision science & technology - 1 Feb 2022

Cai Bincui, Zhang Zhe, Sun Shuo, Lin Tingting, Ke Yifeng, Li Zhiqing, Yang Jin, Li Xiaorong

Abstract excerpt

PURPOSE: The aim of this study was to explore whether there are interactions between genetic (ARMS2/HTRA1) and environmental factors (cigarette smoking) in the pathogenesis of age-related macular degeneration (AMD). METHODS: Primary human retinal pigment epithelial (hRPE) cells were obtained from four donors' eyes with AMD high-risk ARMS2/HTRA1 alleles, and two donors' eyes with wild-type alleles were used as...

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Identifiers

PMID: 35138344
DOI: 10.1167/tvst.11.2.15
PMCID: PMC8842534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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