Article

Probabilities of Fitness Consequences for Point Mutations Across the Human Genome

2014-07-02

Abstract excerpt

We describe a novel computational method for estimating the probability that a point mutation at each position in a genome will influence fitness. These fitness consequence (fit-Cons) scores serve as evolution-based measures of potential genomic function. Our approach is to cluster genomic positions into groups exhibiting distinct “fingerprints” based on high-throughput functional genomic data, then to estimate a...

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Identifiers and source

Literature Corpus work: f36ab628-7934-571f-a901-50459f94f74f
DOI: 10.1101/006825

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