Article
Proteome and secretome profiling of zinc availability in Cryptococcus neoformans identifies Wos2 as a subtle influencer of fungal virulence determinants.
BMC microbiology - 13 Dec 2021
Ball B, Woroszchuk E, Sukumaran A, West H, Afaq A, Carruthers-Lay D, Muselius B, Gee L, Langille M, Pladwig S, Kazi S, Hendriks A, Geddes-McAlister J
Abstract excerpt
BACKGROUND: Fungal infections impact over 25% of the global population. For the opportunistic fungal pathogen, Cryptococcus neoformans, infection leads to cryptococcosis. In the presence of the host, disease is enabled by elaboration of sophisticated virulence determinants, including polysaccharide capsule, melanin, thermotolerance, and extracellular enzymes. Conversely, the host protects itself from fungal...
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