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Article

Cell-specific IRF-3 responses protect against West Nile virus infection by interferon-dependent and -independent mechanisms.

PLoS pathogens - 27 Jul 2007

Daffis Stephane, Samuel Melanie A, Keller Brian C, Gale Michael, Diamond Michael S

Abstract excerpt

Interferon regulatory factor (IRF)-3 is a master transcription factor that activates host antiviral defense programs. Although cell culture studies suggest that IRF-3 promotes antiviral control by inducing interferon (IFN)-beta, near normal levels of IFN-alpha and IFN-beta were observed in IRF-3(-/-) mice after infection by several RNA and DNA viruses. Thus, the specific mechanisms by which IRF-3 modulates viral...

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Source

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Identifiers

PMID: 17676997
DOI: 10.1371/journal.ppat.0030106
PMCID: PMC1933455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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