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Article

Identification of host genes leading to West Nile virus encephalitis in mice brain using RNA-seq analysis

23 May 2016

Abstract excerpt

Differential host responses may be critical determinants of distinct pathologies of West Nile virus (WNV) NY99 (pathogenic) and WNV Eg101 (non-pathogenic) strains. We employed RNA-seq technology to analyze global differential gene expression in WNV-infected mice brain and to identify the host cellular factors leading to lethal encephalitis. We identified 1,400 and 278 transcripts, which were differentially...

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PMID: 27211830
DOI: 10.1038/srep26350

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