Article

Lysosomes are Required for Early Dorsal Signaling in the <i>Xenopus</i> Embryo

2022-01-20

Abstract excerpt

<h4>ABSTRACT</h4> Lysosomes are the digestive center of the cell and play important roles in human disease, including cancer. Previous work has suggested that late endosomes, also known as multivesicular bodies (MVBs), and lysosomes are essential for canonical Wnt pathway signaling. Sequestration of Glycogen Synthase 3 (GSK3) and of β□catenin destruction complex components in MVBs is required for sustained canoni...

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Literature Corpus work: be2372ed-9743-5910-a5fe-17f9c44c5bb2
DOI: 10.1101/2022.01.19.476939

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