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Sperm-inherited organelle clearance in<i>C. elegans</i>relies on LC3-dependent autophagosome targeting to the pericentrosomal area

28 Apr 2015

Abstract excerpt

Macroautophagic degradation of sperm-inherited organelles prevents paternal mitochondrial DNA transmission in C. elegans. The recruitment of autophagy markers around sperm mitochondria has also been observed in mouse and fly embryos but their role in degradation is debated. Both worm Atg8 ubiquitin-like proteins, LGG-1/GABARAP and LGG-2/LC3, are recruited around sperm organelles after fertilization. Whereas LGG-1...

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PMID: 25922527
DOI: 10.1242/dev.117879

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