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Article

Cathepsin-Mediated Alterations in TGFß-Related Signaling Underlie Disrupted Cartilage and Bone Maturation Associated With Impaired Lysosomal Targeting.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Mar 2016

Flanagan-Steet Heather, Aarnio Megan, Kwan Brian, Guihard Pierre, Petrey Aaron, Haskins Mark, Blanchard Frederic, Steet Richard

Abstract excerpt

Hypersecretion of acid hydrolases is a hallmark feature of mucolipidosis II (MLII), a lysosomal storage disease caused by loss of carbohydrate-dependent lysosomal targeting. Inappropriate extracellular action of these hydrolases is proposed to contribute to skeletal pathogenesis, but the mechanisms that connect hydrolase activity to the onset of disease phenotypes remain poorly understood. Here we link...

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Source

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Identifiers

PMID: 26404503
DOI: 10.1002/jbmr.2722
PMCID: PMC4808492

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cathepsin-Mediated Alterations in TGFß-Related Signaling Underlie Disrupted Cartilage and Bone Maturation Associated With Impaired Lysosomal Targeting.PMID 26404503Read ↗

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