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Article

Lysosomes are required for early dorsal signaling in the Xenopus embryo

21 Apr 2022

Abstract excerpt

Lysosomes are the digestive center of the cell and play important roles in human diseases, including cancer. Previous work has suggested that late endosomes, also known as multivesicular bodies (MVBs), and lysosomes are essential for canonical Wnt pathway signaling. Sequestration of Glycogen Synthase 3 (GSK3) and of β‐catenin destruction complex components in MVBs is required for sustained canonical Wnt...

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PMID: 35446621
DOI: 10.1073/pnas.2201008119

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