Article

Germline/soma distinction in <i>Drosophila</i> embryos requires regulators of zygotic genome activation

2022-03-27

Abstract excerpt

In Drosophila melanogaster embryos, somatic versus germline identity is the first cell fate decision. Zygotic genome activation (ZGA) orchestrates regionalized gene expression, imparting specific identity on somatic cells. ZGA begins with a minor wave that commences at nuclear cycle (NC) 8 under the guidance of chromatin accessibility factors (Zelda, CLAMP, GAF), followed by the major wave during NC14. By contras...

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Literature Corpus work: 1def9d44-5fef-5bbd-97f8-447dc4055025
DOI: 10.1101/2022.03.24.485643

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