Comprehensive and Integrated Genomic Characterization of Human Immunome in Cancer

Abstract excerpt

Genetic alterations in immune-related pathways are common hallmarks of cancer. However, to realize the full potential of immunotherapy, a comprehensive understanding of immune networks and how mutations impact network structure and functional output across cancer types is instrumental. Herein we systematically interrogated somatic mutations that could express neoantigens and alter immune responses in cancer patien...

Topics

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• Algorithms
• Gene Regulatory Networks
• Genomics
• Immunotherapy
• Mutation
• Neoplasms
• Transcriptome
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

be1cedfa-b966-5f1c-914a-238c1bce5e7d

DOI

10.1101/2020.06.02.128884