Article
Applications of Immunogenomics to Cancer.
Cell - 9 Feb 2017
Liu X Shirley, Mardis Elaine R
Abstract excerpt
Cancer immunogenomics originally was framed by research supporting the hypothesis that cancer mutations generated novel peptides seen as "non-self" by the immune system. The search for these "neoantigens" has been facilitated by the combination of new sequencing technologies, specialized computational analyses, and HLA binding predictions that evaluate somatic alterations in a cancer genome and interpret their...
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