Article

Salinomycin inhibits epigenetic modulator EZH2 to enhance Death Receptors in Colon Cancer Stem Cells

2020-02-04

Abstract excerpt

Drug resistance is one of the trademark features of Cancer Stem Cells (CSCs). We and others have recently shown that paucity of functional death receptors (DR4/5) on the cell surface of tumor cells is one of the major reasons for drug resistance, but their involvement in the context of in CSCs is poorly understood. By harnessing CSC specific cytotoxic function of salinomycin, we discovered a critical role of epige...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: be0ba335-2445-5724-aba7-aee21f863efa
DOI: 10.1101/2020.02.03.932269

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Salinomycin inhibits epigenetic modulator EZH2 to enhance Death Receptors in Colon Cancer Stem CellsDOI 10.1101/2020.02.03.932269Read

Salinomycin inhibits epigenetic modulator EZH2 to enhance death receptors in colon cancer stem cellsSemantic proximity Read

A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer.Semantic proximity Read

CRISPR screens identify cholesterol biosynthesis as a therapeutic target on stemness and drug resistance of colon cancerSemantic proximity Read

Targeting of cancer stem cells by inhibitors of DNA and histone methylationSemantic proximity Read

LGR5‐Positive Colon Cancer Stem Cells Interconvert with Drug‐Resistant LGR5‐Negative cells and are Capable of Tumor ReconstitutionSemantic proximity Read

Salinomycin exerts anti‐colorectal cancer activity by targeting the β‐catenin/T‐cell factor complexSemantic proximity Read

STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH PathwaySemantic proximity Read

Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem CellsSemantic proximity Read

Drug-resistant breast cancer cell line displays cancer stem cell phenotype and responds sensitively to epigenetic drug SAHASemantic proximity Read

A genome‐wide RNAi screen reveals essential therapeutic targets of breast cancer stem cellsSemantic proximity Read

Salinomycin as a Drug for Targeting Human Cancer Stem CellsSemantic proximity Read

Combinatorial treatment of mammospheres with trastuzumab and salinomycin efficiently targets HER2‐positive cancer cells and cancer stem cellsSemantic proximity Read