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Article

Targeting of cancer stem cells by inhibitors of DNA and histone methylation

25 May 2015

Abstract excerpt

INTRODUCTION: Curative chemotherapy should target cancer stem cells (CSCs). The key characteristics of CSCs are a block in differentiation and an epigenetic signature similar to embryonic stem cells (ESCs). Differentiation by ESCs and CSCs is suppressed by gene silencing through the polycomb repressive complex 2 (PRC2) and/or DNA methylation. PRC2 contains the EZH2 subunit, which catalyzes the trimethylation of...

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PMID: 26004134
DOI: 10.1517/13543784.2015.1051220

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