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Salinomycin inhibits epigenetic modulator EZH2 to enhance death receptors in colon cancer stem cells

8 Jul 2020

Abstract excerpt

Drug resistance is one of the trademark features of Cancer Stem Cells (CSCs). We and others have recently shown that paucity of functional death receptors (DR4/5) on the cell surface of tumour cells is one of the major reasons for drug resistance, but their involvement in the context of in CSCs is poorly understood. By harnessing CSC specific cytotoxic function of salinomycin, we discovered a critical role of...

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PMID: 32635858
DOI: 10.1080/15592294.2020.1789270

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