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A genome‐wide RNAi screen reveals essential therapeutic targets of breast cancer stem cells

2 Sept 2019

Abstract excerpt

Therapeutic resistance is a major clinical challenge in oncology. Evidence identifies cancer stem cells (CSCs) as a driver of tumor evolution. Accordingly, the key stemness property unique to CSCs may represent a reservoir of therapeutic target to improve cancer treatment. Here, we carried out a genome-wide RNA interference screen to identify genes that regulate breast CSCs-fate (bCSC). Using an...

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PMID: 31476112
DOI: 10.15252/emmm.201809930

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