Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH Pathway

21 Aug 2017

Abstract excerpt

Abstract NOTCH signaling exerts essential roles in normal and malignant intestinal physiology and the homeostasis of cancer stem-like cells (CSC), but the basis for this latter role remains obscure. The signaling scaffold protein STRAP is upregulated in several cancers, where it promotes tumorigenicity and metastasis. Here we report a novel oncogenic function for STRAP in maintaining CSC subpopulations in a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Epigenetics and DNA Methylation
Share to Mechanisms of cancer metastasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28827371
DOI: 10.1158/0008-5472.can-17-0286

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH PathwayPMID 28827371Read ↗

PCGF1 promotes epigenetic activation of stemness markers and colorectal cancer stem cell enrichment.Semantic proximity Read ↗

Role and molecular mechanism of stem cells in colorectal cancer initiationSemantic proximity Read ↗

EZH2 promotes colorectal cancer stem-like cell expansion by activating p21cip1-Wnt/β-catenin signalingSemantic proximity Read ↗

CSN6–TRIM21 axis instigates cancer stemness during tumorigenesisSemantic proximity Read ↗

SKP1 promotes YAP-mediated colorectal cancer stemness via suppressing RASSF1Semantic proximity Read ↗

G9a controls pluripotent-like identity and tumor-initiating function in human colorectal cancerSemantic proximity Read ↗

SKP1 promotes YAP-mediated colorectal cancer stemness via suppressing RASSF1Semantic proximity Read ↗

Notch receptor/ligand diversity: contribution to colorectal cancer stem cell heterogeneitySemantic proximity Read ↗

Musashi-1 promotes a cancer stem cell lineage and chemoresistance in colorectal cancer cellsSemantic proximity Read ↗

SOX4 maintains the stemness of cancer cells via transcriptionally enhancing HDAC1 revealed by comparative proteomics studySemantic proximity Read ↗

Deciphering the Role of Intestinal Crypt Cell Populations in Resistance to Chemotherapy.Semantic proximity Read ↗

Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.