Article

From Patient to Tumor Organoid: Culture Protocol Choice Controls Glioblastoma Tumor Architecture and Identity

2026-05-01

Abstract excerpt

<h4>Background</h4> Patient-derived tumor organoids are widely used in cancer research, yet the biological impact of tissue processing during model generation remains unclear. Fragment-based and dissociation-based approaches are commonly assumed to trade fidelity for uniformity, but their molecular consequences remain incompletely defined. <h4>Methods</h4> We performed a proteome-wide comparison of fragment-base...

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Literature Corpus work: be0386b4-4870-50dd-b036-d7a5312931bc
DOI: 10.64898/2026.04.28.721493

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