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Article

Atopic Dermatitis Susceptibility Variants in Filaggrin Hitchhike Hornerin Selective Sweep.

Genome biology and evolution - 11 Nov 2016

Eaaswarkhanth Muthukrishnan, Xu Duo, Flanagan Colin, Rzhetskaya Margarita, Hayes M Geoffrey, Blekhman Ran, Jablonski Nina G, Gokcumen Omer

Abstract excerpt

Human skin has evolved rapidly, leaving evolutionary signatures in the genome. The filaggrin (FLG) gene is widely studied for its skin-barrier function in humans. The extensive genetic variation in this gene, especially common loss-of-function (LoF) mutations, has been established as primary risk factors for atopic dermatitis. To investigate the evolution of this gene, we analyzed 2,504 human genomes and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27678121
DOI: 10.1093/gbe/evw242
PMCID: PMC5174745

Genes

FLG
HRNR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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