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Local Adaptation of Sun-Exposure-Dependent Gene Expression Regulation in Human Skin

19 Oct 2016

Abstract excerpt

Sun-exposure is a key environmental variable in the study of human evolution. Several skin-pigmentation genes serve as classical examples of positive selection, suggesting that sun-exposure has significantly shaped worldwide genomic variation. Here we investigate the interaction between genetic variation and sun-exposure, and how this impacts gene expression regulation. Using RNA-Seq data from 607 human skin...

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PMID: 27760139
DOI: 10.1371/journal.pgen.1006382

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