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Novel EAAT2 activators improve motor and cognitive impairment in a transgenic model of Huntington’s disease

7 Jun 2023

Abstract excerpt

Introduction Glutamate excitotoxicity is causal in striatal neurodegeneration underlying motor dysfunction and cognitive deficits in Huntington’s disease (HD). Excitatory amino acid transporter 2 (EAAT2), the predominant glutamate transporter accounting for >90% of glutamate transport, plays a key role in preventing excitotoxicity by clearing excess glutamate from the intrasynaptic cleft. Accordingly, EAAT2 has...

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PMID: 37351153
DOI: 10.3389/fnbeh.2023.1176777

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