Article

Deciphering the tumor-specific immunopeptidome <i>in vivo</i> with genetically engineered mouse models

2021-07-01

Abstract excerpt

Effective immunosurveillance of cancer requires the presentation of peptide antigens on major histocompatibility complex Class I (MHC-I). Recent developments in proteomics have improved the identification of peptides that are naturally presented by MHC-I, collectively known as the “immunopeptidome”. Current approaches to profile tumor immunopeptidomes have been limited to in vitro investigation, which fails to ca...

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Literature Corpus work: bda26777-d197-5425-aa16-ea2199214af4
DOI: 10.1101/2021.06.30.450516

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