Article
Identification of Tumor Antigens in the HLA Peptidome of Patient-derived Xenograft Tumors in Mouse.
Molecular & cellular proteomics : MCP - 1 Aug 2020
Rijensky Nataly Mancette, Blondheim Shraga Netta R, Barnea Eilon, Peled Nir, Rosenbaum Eli, Popovtzer Aron, Stemmer Solomon M, Livoff Alejandro, Shlapobersky Mark, Moskovits Neta, Perry Dafna, Rubin Eitan, Haviv Itzhak, Admon Arie
Abstract excerpt
Personalized cancer immunotherapy targeting patient-specific cancer/testis antigens (CTA) and neoantigens may benefit from large-scale tumor human leukocyte antigen (HLA) peptidome (immunopeptidome) analysis, which aims to accurately identify antigens presented by tumor cells. Although significant efforts have been invested in analyzing the HLA peptidomes of fresh tumors, it is often impossible to obtain...
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