Article

Bateman domains and adenosine derivatives form a binding contract

2004-01-15

Abstract excerpt

Conserved pairs of CBS sequence motifs (named after cystathionine β-synthase) found in a wide variety of proteins associate to form Bateman domains. A new study establishes that Bateman domains bind adenosyl compounds and regulate IMP dehydrogenase, CBS, chloride channels, and AMP-activated protein kinase. This discovery reveals how mutations in CBS sequences in these proteins cause hereditary diseases and provide...

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Literature Corpus work: bd79b885-9bd0-5e01-80ca-71b8fb13855f
DOI: 10.1172/jci200420846

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