Article
CBS domains: structure, function, and pathology in human proteins.
American journal of physiology. Cell physiology - 1 Dec 2005
Ignoul Sofie, Eggermont Jan
Abstract excerpt
The cystathionine-beta-synthase (CBS) domain is an evolutionarily conserved protein domain that is present in the proteome of archaebacteria, prokaryotes, and eukaryotes. CBS domains usually come in tandem repeats and are found in cytosolic and membrane proteins performing different functions (metabolic enzymes, kinases, and channels). Crystallographic studies of bacterial CBS domains have shown that two CBS...
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