Article

Dimerization and Threonine-Dependent Stabilization Govern Human YRDC Catalysis

2025-12-05

Abstract excerpt

Addition of N 6 -threonylcarbamoyladenosine occurs at position 37 (t⁶A 37 ) of five mitochondrial tRNA species, influencing translation fidelity and efficiency. Mutations in YRDC, the enzyme catalyzing the first step in t⁶A 37 synthesis, cause severe neurological and renal diseases in humans, including in Galloway-Mowatt disease (GAMOS). YRDC generates threonylcarbamoyl-AMP (TC-AMP) using ATP, threonine and bic...

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Literature Corpus work: 1c4076a4-3aee-59b2-bfd3-1aeb2489e4a2
DOI: 10.64898/2025.12.03.692196

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